Low Testosterone And Early Death In Men

Testosterone is a principal androgen, or male sex hormone. Testosterone levels decline gradually and because it comes on slowly, men and women often accommodate to the symptoms and do not realize how much they have lost.

A recent report in the Archives of Internal Medicine links reduced levels of testosterone in men to an increased risk of mortality during up to eight years of follow-up. Scientists recently analyzed the association between testosterone levels and mortality in 858 male veterans over the age of 40. Testosterone levels were measured at least twice between 1994 and 1999. The subjects were followed through 2002. Nineteen percent of the participants had a low total testosterone level or a low free testosterone level, while 53% had normal levels and 28% had balanced levels.

Testosterone levels in men progressively decline after the age of 30, which can eventually result in a loss of muscle mass and bone density; diminished energy and libido, and symptoms of depression and irritability. While 20% of the men with normal testosterone died during follow-up, deaths occurred among 25% of those with balanced levels and 35% of those with low levels. After adjusting for age, illness, and other factors, men with low testosterone had an 88% higher risk of dying over the course of follow-up compared to men with normal levels. To reduce the effect of acute illness, the researchers then excluded men who died within the first year of follow-up, yet still found a 68% greater risk of death among men with low testosterone.

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