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Resveratrol is acquiring growing recognition for its promise in fighting age-related diseases ranging from dementia to diabetes. Up to now, the most reliable, and heavily researched way to extend life span is through the practice of caloric restriction, which involves reducing calorie intake while simultaneously maintaining good nutritional status. Innumerable studies, restricting calorie intake in laboratory animals has proved to prolong their life span by as much as 6O%. While scientists have not yet ascertained that caloric restriction extends life span in humans, the preliminary evidence is very promising. In humans, consuming a low-calorie diet is associated with several possible markers of greater longevity, such as lower insulin levels and reduced body temperatures, along with less of the chromosomal damage that typically accompanies aging. Furthermore, people who consume a low-calorie diet may be less prone to diseases associated with being overweight or obese, such as metabolic syndrome, diabetes, cancer, and atherosclerosis.
Interest in resveratrol has produced several recent discoveries. In a landmark study, Harvard University scientists showed that resveratrol could prolong survival by regulating a gene associated with aging that is present in all life forms. They demonstrated that while middle-aged mice fed a high-calorie diet suffered the ravages of obesity-including metabolic changes resembling diabetes, liver and heart damage, and premature death, mice that were fed resveratrol in addition to the high-calorie diet actually exhibited beneficial changes in their physiology resembling those of mice fed a standard diet. Also mice on the non-supplemented high-calorie diet developed enlarged, fatty livers, resveratrol supplementation prevented these changes. heart disease and evidence of atherosclerosis were seen in mice fed the high-calorie diet, but not in those that were also given resveratrol. Resveratrol significantly increased survival, reducing the risk of death from the high-calorie diet by 31%. Together, these findings offer powerful evidence that resveratrol protected the animals from the harmful effects of a high-calorie diet.
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