ALA and ALC

There have been numerous studies showing benefit for reducing effects of aging of the brain, especially with use of alpha lipoic acid (ALA) and acetyl-L-carnitine (ALC). There have actually been studies going back to the 1980s and even prior, demonstrating safety and efficacy for these two nutrients, both individually and in combination. In one study published in the 1990s, aged mice were given a combination of these two nutrients. There was a review article published in the November 2004 edition of the Annals of New York Academy of Science by Dr. Bruce Ames. Dr. Ames, in the article, indicates that oxidative mitochondrial decay was a major contributor to aging. He notes that feeding old rats ALA and ALC for a few weeks restored mitochondrial function. In addition, it lowered oxidants, neuron RNA oxidation and certain mutagenic aldehydes. He further notes that a recent meta-analysis of twenty one double-blinded clinical trials of ALC in humans with mild cognitive impairment showed significant efficacy versus placebo. He also notes a meta-analysis of four clinical trials of ALA in humans with unhealthy blood sugar and poor nerve function indicated benefits when compared with placebos.

In a study published in the journal Diabetes Care in January 2005, researchers from Wayne State University in Michigan evaluated data bases from two, 52-week randomized, placebo-controlled clinical trials in patients suffering with nerve damage from elevated blood sugar. Both of these trials used doses of ALC 500 mg and 1,000 mg three times daily, for a total of 1,500 mg to 3,000 mg per day. A total of over 1,200 patients were enrolled in these studies. Aside from clinical symptoms scores, nerve conduction velocities were also evaluated. The data showed significant improvement in regeneration of nerve fiber clusters. Although nerve conduction velocities and amplitudes did not improve, sensory perception did improve in both studies. The studies indicated that ALC supplementation was efficacious in alleviating pain and improving nerve fiber regeneration in patients with nerve damage from high blood sugar.

Combining these 3 is Powerful:CoQ10 + AlphaLipoicAcid (ALA) + AcetylLCarnitine(ALC).The Big 3 To Prevent Aging Problems.